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Hydroxypropyl methyl cellulose (E 464) is identified with the single Chemical Abstracts Service (CAS) number 9004-65-3, and the European Inventory of Existing Chemical Substances (EINECS) number 232-674-9. It is manufactured reacting partially depolymerised cellulose with methyl groups and containing a small degree of hydroxypropyl substitution (Figure 11). Since cellulose is a high molecular weight linear polysaccharide of indeterminate mass and its degree of substitution will depend on the conditions of manufacture, a unique mass and structure cannot be specified. HPMC is in the form of white to off-white powder. A generalised structure of HPMC is shown in Figure 11