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TiO₂ is also used in oral pharmaceutical formulations, and the Pharmaceutical Excipients handbook considers nano-sized TiO₂ a non-irritant and non-toxic excipient. Despite the fact that TiO₂ submicron- and nano-sized particles are widely used as food and pharmaceutical additives, information on their toxicity and distribution upon oral exposure is very limited.

Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive, commented Matthew Wright, member of the EFSA's Food Additives and Flavourings Panel in a press statement.