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A significant body of research, mostly from rodent models and in vitro studies, has linked titanium dioxide with health risks related to the gut, including intestinal inflammation, alterations to the gut microbiota, and more. It is classified by the International Agency for Research on Cancer (IARC) in Group 2B, as possibly carcinogenic to humans.

Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

According to the feedback of manufacturers, the recent mainstream factory new single price, the market as a whole into the center of gravity. On the demand side, the terminal in August is still the off-season, many downstream still have inventory use, the current batch purchase intention is limited, and the market turnover is low. Some plastics and papermaking related downstream feedback part of the signal price is high. Recent titanium dioxide raw material price shock is strong, titanium dioxide price upward support has been enhanced, comprehensive market factors, the current titanium dioxide market into the stable price state after rising.