Generally, HPMC with a higher DS and a lower molecular weight tends to be more soluble in ethanol. This is because the higher degree of substitution introduces more polar groups along the polymer chain, increasing its affinity for ethanol This is because the higher degree of substitution introduces more polar groups along the polymer chain, increasing its affinity for ethanol This is because the higher degree of substitution introduces more polar groups along the polymer chain, increasing its affinity for ethanol This is because the higher degree of substitution introduces more polar groups along the polymer chain, increasing its affinity for ethanolhpmc solubility in ethanol. Similarly, a lower molecular weight allows the polymer chains to pack more loosely, making it easier for them to interact with the solvent molecules.