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Allergies and Sensitivities: While capsicum oleoresin is generally safe, individuals with known allergies to peppers or related plants should exercise caution. Allergic reactions to capsicum oleoresin can occur in sensitive individuals, leading to symptoms such as skin rashes, hives, or, in severe cases, anaphylaxis. It's important for individuals with known allergies to carefully read food labels and avoid products containing capsicum oleoresin.

When substituting, use common sense. Cayenne pepper is as much as 50 times hotter than sweet paprika, so a 1:1 substitution wouldn't work unless you want some heat—the right substitution, in this case, would be 1/3 of a teaspoon of cayenne per 1 teaspoon of paprika. Make an informed decision, but also use thorough recipes that might suggest reasonable substitutions.

Paprika is a good source of vitamin E, which is an antioxidant that helps protect cells from damage. It also contains vitamin A, vitamin K, and vitamin B6. In addition, paprika has some minerals like zinc, magnesium, phosphorus, and potassium.