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The National Cancer Institute tested TiO₂ for possible carcinogenicity by the oral route of exposure by feeding rats and mice with TiO₂ (size not specified) at doses 25,000 or 50,000 ppm TiO₂ for 103 weeks. They concluded that TiO₂ was not carcinogenic.Also, the study with rats fed diets containing up to 5 % TiO₂ coated mica for 130 weeks showed no treatment-related carcinogenicity. Since the size and other TiO₂ properties were not specified or determined, we cannot generalize this conclusion and we have to take into account other possible outcomes of this scenario in different exposure conditions (other size/crystalline structure of TiO₂ etc.).

Then, there’s ultrafine-grade, also known as nanoscale titanium dioxide. This is used for its ability to scatter lightly as an ultra-fine powder. This gives it the ability to lightly absorb into the skin while providing a bit of transparency. Below, we’ll go more into the cosmetic uses of these two forms of titanium dioxide.

On the other hand, titanium dioxide is a synthetic mineral that is produced through a chemical reaction involving the mineral ilmenite or rutile. It is used in industries such as cosmetics, paint, and sunscreen as a whitening agent and pigment. The manufacturing process of titanium dioxide involves extracting the mineral from ores, purifying it through chemical processes, and then grinding it into a fine powder.