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Lithopone is a white pigment (PW5) co-precipitated from solutions of zinc and barium salts according to the following reaction: 

Is Titanium Dioxide Safe?

The EU expert panel did not identify an immediate health concern linked to TiO₂ when used as a food additive. However, due mainly to uncertainties concerning the safety of TiO₂ nanoparticles, the panel concluded that TiO₂ as a food additive (E171) could no longer be considered safe.

Importantly, TiO2 also has a very high refractive index (its ability to scatter light), even higher than diamond. This makes it an incredibly bright substance and an ideal material for aesthetic design use.

Lithopone has therefore traditionally been used in stoppers and putties, jointing compounds and sealing compounds, primers and undercoats and in road-marking paints.

Manufacturers use titanium dioxide in some packaging to protect food from exposure to sunlight. Lab studies show it may also help stop bacteria from growing, and break down a gas that makes many fruits and vegetables ripen faster. That can keep products fresher and give them a longer shelf life.