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Faber argued there hasn't been enough change in these federal regulations in the decades following the FDA's approval of titanium dioxide – especially as others increasingly point to potential health consequences.

Available studies in humans and postmortem analysis of tissues suggested that the oral bioavailability of titanium dioxide in humans is very low. JECFA noted that there are currently no epidemiological studies that allow any conclusions to be drawn with respect to an association between dietary exposure titanium dioxide and human health effects.