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While E460 is generally recognized as safe by food safety authorities such as the FDA and EFSA, it is not without its controversies. Some health professionals argue that while cellulose is a natural substance, its processing into E460 may lead to concerns about its impact on digestion. For instance, overly processed cellulose could lead to gastrointestinal issues if consumed in excessive amounts.

However, like any additive, sodium citrate may pose risks for certain individuals. People with specific conditions such as allergies to citric acid or sodium, or those on sodium-restricted diets, should be mindful of their consumption. It is advisable for consumers to read product labels carefully to be aware of the additives included in their foods.

Despite their benefits, the use of inorganic fertilizers is not without controversy. One major concern is the environmental impact associated with their application. Excessive use of inorganic fertilizers can lead to soil degradation and water pollution, particularly through runoff that contaminates lakes and rivers, causing eutrophication. This process results in algal blooms that deplete oxygen in water bodies, harming aquatic life.