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In general, nanoparticles have been shown to accumulate in the body, particularly in organs in the gastrointestinal tract, along with the liver, spleen, and capillaries of the lungs.

However, humans are not exposed to E171 in drinking water at any significant quantity over a long duration, so this potential effect is irrelevant to the human experience. It’s important to understand that a potential hazard is not the same thing as an actual risk.