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From studies deemed relevant, the experts found that titanium dioxide as a food additive is poorly absorbed by the gastrointestinal tract of mice and rats, with no adverse effects observed in short-term studies in rodents receiving titanium dioxide in their diets. No observed adverse effect levels (NOAELs) of 15,000 milligrams per kilogram of bodyweight (mg/kg BW) per day and 5,000 mg/kg BW per day—the highest doses tested—were established for mice and rats, respectively.

In recent years, environmental concerns have shaped the way lithopone is produced and used. Suppliers are now more attentive to the sustainability aspect of their operations, ensuring that lithopone is sourced from eco-friendly processes. Many suppliers have adopted responsible mining practices and have invested in technologies that reduce waste and emissions during production. This shift not only appeals to environmentally-conscious consumers but also helps manufacturers comply with stringent regulations regarding product safety and environmental impact.

Titanium dioxide is added to some food packaging to preserve the shelf life of a product.