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Conclusion

CIR Safety Review: Sorbic Acid and Potassium Sorbate were practically nontoxic in acute oral toxicity studies. In subchronic studies, no significant adverse effects were observed when 10% Sorbic Acid was included in the diet. Sorbic Acid and Potassium Sorbate, at concentrations up to 10%, were practically nonirritating to the eye. Both ingredients at concentrations up to 10% were at most only slightly irritating to skin. Sorbic Acid and Potassium Sorbate have been tested for mutagenic effects using bacterial tests, genetic recombination tests, reversion assays, tests for chromosomal aberrations, sister chromatid exchanges and gene mutations. The weight of evidence of these tests indicates that these ingredients were not mutagenic. Potassium Sorbate at 0.1% in the diet or 0.3% in drinking water for up to 100 weeks was not carcinogenic. In other chronic studies, no carcinogenic effect was demonstrated by Sorbic Acid in diets containing up to 10% Sorbic Acid. No developmental effects have been observed with Potassium Sorbate. Formulations containing up to 0.5% Sorbic Acid and or Potassium Sorbate were not significant primary or cumulative irritants and not sensitizers.

In the field of pharmaceuticals, hydroxybenzotriazole has also shown promise as a potential building block for the synthesis of various medicinal compounds. The unique structural properties of HBTA can facilitate chemical reactions that are critical in drug development. This aspect opens up new avenues for research and application within medicinal chemistry, further underscoring the compound's versatility.

Despite its popularity, MSG has often faced criticism and health concerns. In the 1960s, the term Chinese Restaurant Syndrome emerged, attributing various symptoms such as headaches and nausea to the consumption of MSG-rich foods. These claims ignited widespread fear and misconceptions about the safety of MSG. However, extensive scientific research has since debunked the myth of MSG as a hazardous ingredient. The U.S. Food and Drug Administration (FDA), along with numerous health organizations, has classified MSG as generally recognized as safe (GRAS). Literature reviews have shown that there is no substantial evidence linking MSG to the adverse health effects that were once widely reported.

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