Key Points/Overview

In a 2017 study published in Scientific Reports, researchers exposed rats to human-relevant levels of E171 to examine the effects of intestinal inflammation and carcinogenesis. They saw that “a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model.” They continued: “Stimulation of immune cells isolated from Peyer’s Patches [which are clusters of lymphoid follicles found in the intestine] showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased,” researchers wrote. “A 100-day titanium dioxide treatment promoted colon microinflammation and initiated preneoplastic lesions.” The scientists concluded: “These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.”

Lithopone

Overall, the use of TiO2 in factory settings plays a crucial role in enhancing the quality, performance, and appearance of a wide range of products. Its unique properties make it an invaluable ingredient in various industrial processes, allowing manufacturers to create high-quality, durable, and visually appealing finishes. As technology continues to advance, the demand for TiO2 is expected to grow, further solidifying its importance in the manufacturing industry.