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The degree of degradation largely depends on the type of rubber and the concentration of acetone. Natural rubber, for example, is more susceptible to acetone than synthetic rubbers such as butyl or neoprene. Therefore, when processing or utilizing acetone in environments with rubber materials, it's crucial for manufacturers and users to consider the compatibility of these substances. Testing small samples can be a prudent approach to ascertain how a specific rubber type reacts to acetone.

The safety of E551 as a food additive has been thoroughly assessed by regulatory authorities worldwide. The European Food Safety Authority (EFSA) and the U.S. Food and Drug Administration (FDA) have both classified E551 as safe for consumption within specified limits. Moreover, studies have shown that, when consumed in moderation, E551 does not pose any health risks to consumers. This regulatory backing bolsters the confidence of manufacturers in using this agent to enhance their products.