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In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone. 

One of the key challenges facing TiO2 industry suppliers is the fluctuation of raw material prices. The production of TiO2 requires raw materials such as ilmenite or rutile, which are subject to market price volatility. Suppliers must carefully monitor these fluctuations and adjust their production processes accordingly to ensure profitability.

In the context of titanium dioxide determination, the process generally begins with the sample preparation, where a known mass of the sample containing TiO2 is dissolved or digested appropriately. The subsequent steps involve adding a precipitating agent, such as ammonium sulfate or sulfuric acid, to the prepared solution, which facilitates the formation of a titanium precipitate. This precipitate is often titanium hydroxide, which is not only insoluble but can be easily filtered out from the liquid phase.