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Curcumin has been approved by the US Food and Drug Administration as a soothing compound. The recommended extreme daily doses range is from 3 mg/kg to 4-10 g/day. Since most studies using the extract have a time limit of 1-3 months, to date, there is no evidence of any long-term consequences from long-term use of curcumin. Although there have been no reports of serious adverse reactions to curcumin use, some side effects may include diarrhea, head pain, skin rashes, and yellow stools.