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Respiratory Exposure 

One of the most common worries about titanium dioxide is that it could be a cancer-causing agent. The link between cancer and titanium dioxide traces back to a 1985 study where rats were exposed to high levels of titanium dioxide for two years, causing lung cancer. However, not all experts are convinced by this study.

Moreover, the region of sourcing can also impact pricing. Suppliers in different geographical locations may offer varied prices due to differences in transportation costs, availability of raw materials, and local market conditions. Buyers must consider these regional variances when negotiating prices and establishing long-term relationships with suppliers. In many cases, sourcing from manufacturers that can produce high-quality lithopone pigments at competitive rates can lead to significant cost savings.

The gastrointestinal tract is a complex barrier/exchange system, and is the most important route by which macromolecules can enter the body. The main absorption takes place through villi and microvilli of the epithelium of the small and large intestines, which have an overall surface of about 200 m². Already in 1922, it was recognized by Kumagai, that particles can translocate from the lumen of the intestinal tract via aggregation of intestinal lymphatic tissue (Peyer’s patch, containing M-cells (phagocytic enterocytes)). Uptake can also occur via the normal intestinal enterocytes. Solid particles, once in the sub-mucosal tissue, are able to enter both the lymphatic and blood circulation.