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Earlier this year, a bill was introduced in the California legislature to ban the manufacture, sale and distribution of foods in the state containing titanium dioxide, along with four other harmful food chemicals. 

A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO₂. However, these same effects were not seen when the same or higher doses of food-grade TiO₂ were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO₂ from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

Lithopone is manufactured by a process (Fig. 1) in which barium sulfide solution is prepared by reducing barite ore (BaSO ₄) with carbon and leaching the resulting mass.