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For a long time, the only material used to make capsule shells was gelatine. Gelatine is obtained from the skin and bones of various animal species, especially pigs and cattle. Due to strict regulations on the use of gelatine caused by emerging diseases such as TSE (Transmissible Spongiform Encephalopathy), which includes BSE (Bovine Spongiform Encephalopathy), the search for a substitute for gelatine was encouraged.
Plant-based capsules have also been available on the market since 1998. With HPMC, consumers have a completely safe, plant-based product at their disposal, so that vegans or vegetarians and people who abstain from gelatine due to their religion also have an alternative to gelatine capsules.
HPMC capsules can withstand high temperatures and high humidity and have a low inherent moisture content. This makes the capsule shells suitable for storing moisture-sensitive ingredients. They therefore protect their contents from all kinds of fluctuations, such as temperature fluctuations and humidity. HPMC capsules can therefore be stored well in all climate zones. In contrast, gelatine capsule shells have a lower water content. They therefore quickly become brittle at low humidity.
Despite the many advantages of HPMC capsules, gelatine capsules are still the most commonly used type of capsule in the pharmaceutical industry. One reason for this is probably the lower price.