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In summary, when used in accordance with regulatory guidelines and recommended usage levels, capsicum oleoresin is considered safe for consumption in food products. However, individuals with known allergies or sensitivities should exercise caution, and it's important to ensure the purity and quality of the product. As with any food ingredient, moderation and informed use are key to ensuring its safe consumption.

If it's just a small amount, like half a teaspoon or less, you could conceivably get away with substituting chili powder, which is mainly paprika along with other seasonings such as garlic, salt, cumin, and a bit of cayenne. It's slightly hotter than plain paprika, but not overwhelmingly so. Some other ground red peppers like ancho chili powder, chipotle powder, or hot sauce would also work. Chili powder will also suffice if the paprika is just being used for a garnish. With these spices, you can go with a 1:1 ratio of the substitute spice to the paprika amount needed.