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In terms of application, meticulous preparation and attention to detail yield the best results. For paint grinders, maintaining a ratio of 12 pounds of refined linseed oil to 88 pounds of lithopone pigment will provide optimal workability. A salient factor that should be heeded is the state of the lithopone before mixing with oil; the material must be sufficiently dry. Only then will it integrate seamlessly with the oil, ensuring that the resultant mixture possesses the desired consistency and properties.

Inhaling high concentrations of titanium dioxide dust or fumes, which may occur in occupational settings — such as in the production or processing of products containing the mineral — may cause respiratory problems like coughing, wheezing and shortness of breath, in addition to eye and skin irritation.