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The concern from animal studies is that high amounts of titanium dioxide have increased inflammation and colon tumor formation, said Dr. Johnson-Arbor. A 2021 review, meanwhile, suggested that using titanium dioxide as a food additive weakens the gut lining and worsens the progression of inflammatory bowel disease.

2. Cosmetics With its UV-filtering properties, anatase TiO2 is a popular ingredient in sunscreens and cosmetic formulations. Its ability to scatter UV radiation effectively protects the skin from harmful sun exposure, contributing to the increasing popularity of natural and mineral makeup products.