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Titanium dioxide has also been classified as a possible human carcinogen by the International Agency for Research on Cancer, which has caused concern about its use in food products. This classification, however, is currently based on limited evidence from animal studies that involved the inhalation of titanium dioxide particles that increased the risk of lung cancer.

Overall, the Food Directorate's comprehensive review of the available science of TiO₂ as a food additive showed:

Panzhihua Dongfang Titanium Industry Co., Ltd. Dongfang, a well-known brand of titanium dioxide, a famous brand in Sichuan, a high-tech enterprise, a large supplier of titanium dioxide and titanium sponge, and one of the largest/leading titanium raw material production bases in China.