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When assessing HPMC’s solubility in organic solvents, one must consider the nature of the solvent itself. HPMC generally exhibits poor solubility in non-polar solvents such as hexane and toluene. These solvents lack the ability to disrupt the extensive hydrogen bonding network created by the hydroxyl groups on the HPMC molecule. In contrast, HPMC shows better solubility in polar organic solvents that can solvate the polymer effectively. Solvents such as ethanol, isopropanol, and acetone are more suitable for dissolving HPMC due to their ability to interact favorably with the hydrophilic segments of the polymer.
hpmc solubility in organic solvents
