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Hydroxypropyl methyl cellulose (HPMC) is a cellulose derivative that was first developed and used in industrial and food applications starting in the 20th century. Its exact origin in terms of discovery and initial development is difficult to attribute to a single individual or organization, as research and development of cellulose derivatives has involved many scientists and companies at different times.

HPMC is produced through a chemical process known as etherification, in which natural cellulose is treated with hydroxypropyl chloride and sodium methoxide. This process alters the chemical structure of cellulose, making it water-soluble and giving it desired properties as a thickener, stabilizer and film-forming agent.

Production and Use over Time:

The use of HPMC in industrial and food applications has grown significantly since the mid-20th century, when researchers began to more fully explore the potential uses of cellulose derivatives. Its ability to act as a thickener, emulsifier and stabilizer has increased its adoption in a variety of industries, including pharmaceuticals, cosmetics and food.