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Despite their widespread use and effectiveness, sulfite preservatives have stirred controversy, primarily due to health concerns. A small percentage of the population, particularly those with asthma, may experience allergic reactions to sulfites, which can include symptoms such as difficulty breathing, headaches, and digestive issues. Given the potential for such reactions, regulatory bodies, including the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA), mandate that foods containing sulfites at levels above 10 parts per million must be clearly labeled. This transparency allows consumers to make informed choices regarding their dietary intake.

Sulfur dioxide — Commonly used in dried fruit to prevent discoloration or to prevent bacterial growth in wine. The use of sulfites, including sulfur dioxide, to preserve fresh fruits and vegetables has been banned by the FDA for over 35 years, and they cannot be used on foods that are sources of vitamin B1. Those with asthma or sulfite allergies should avoid it, but for others it is regarded as safe.

One significant advantage of Sodium Benzoate is its ability to prolong shelf life without altering the taste of the food significantly. However, it is essential to use it within recommended limits. In the European Union, the allowable limit for E211 is typically up to 0.1% in food products. Higher concentrations can lead to safety concerns, particularly when combined with ascorbic acid (Vitamin C), which can result in the formation of benzene, a known carcinogen. This potential health risk has sparked ongoing scrutiny and research, leading to regulatory review and strict compliance measures for manufacturers.