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Titanium dioxide prices in the Asian market skyrocketed due to high demand and limited stock availability. Prices in the Chinese market surged significantly, reaching 2875 USD /MT at the end of March, well above the USD 2015/MT level in January 2021.

In a 2022 study published in the Journal of Hazardous Materials, scientists wanted to examine the effects of titanium dioxide as a food additive on atherosclerosis in mice. (Atherosclerosis refers to a hardening of the arteries.) Researchers fed mice 40 mg/kg of the food additive every day for 4 months, and found that it not only altered gut microbiota but also led to a significantly increased atherosclerotic lesion area, especially in animals that consumed a high-choline western diet (HCD).